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Spleen - Anatomy & Physiology (view source)
Revision as of 16:10, 17 July 2008
, 16:10, 17 July 2008→Structure
<p>The spleen develops in association with the digestive system in the dorsal mesogastrium, and as the stomach rotates during development the spleen comes to occupy the left cranial abdomen. Haematopoietic cells in the spleen are derived from the AGM (aorta-gonad-mesonephros) and yolk sac and as the primary lymphoid organs become established it becomes populated with T and B lymphocytes.</p>
<p>The spleen develops in association with the digestive system in the dorsal mesogastrium, and as the stomach rotates during development the spleen comes to occupy the left cranial abdomen. Haematopoietic cells in the spleen are derived from the AGM (aorta-gonad-mesonephros) and yolk sac and as the primary lymphoid organs become established it becomes populated with T and B lymphocytes.</p>
==Structure==
==Structure==
{|align="right"
|[[Image:LH_Spleen_Equine_Ultrasound.jpg|150px]]
|[[Image:LH_Spleen_Histology.jpg|150px]]
|-
!<p>Normal Ultrasound</p> (Equine)
!Histological section
|-
|colspan="2"|<center><sup>©Nottingham Uni 2008 </sup></center>
|}
<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the stomach by the greater omentum. The spleen is covered in a enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae. </p>
<p>The spleen lies vertically on the left side of the cranial abdomen. It is attached to the greater curvature of the stomach by the greater omentum. The spleen is covered in a enclosed in a capsule of fibrous and elastic tissue that extends into the parenchyma as trabeculae. </p>
<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp. The red and white pulp are separated by the marginal sinus.</p>
<p> The parenchyma is supported by a fine mesh of reticular fibres and is divided into two types of tissue, the red and the white pulp. The red and white pulp are separated by the marginal sinus.</p>
====Species Differences====
====Species Differences====
{|align="right"
{|align="right"
|[[Image:LH_Spleen_Equine_photo.jpg|110px|<p>'''Equine spleen'''</p>]]
|[[Image:LH_Spleen_Equine_photo.jpg|110px]]
|[[Image:LH_Spleen_Bovine_photo.jpg|156px|<p>'''Bovine Spleen'''</p>]]
|[[Image:LH_Spleen_Bovine_photo.jpg|156px]]
|-
|-
!Equine
!Equine
===Histology===
===Histology===
<gallery perrow="3">
<gallery perrow="3">
Image:LH_Spleen_Rat_Histology.jpg|<p>'''Gross view (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_Histology.jpg|<p>'''Red & white Pulp (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_2_Histology.jpg|<p>'''Central artery & PALS (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_2_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_3_Histology.jpg|<p>'''Trabecula and capsule (rat) '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_3_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_4_Histology.jpg|<p>'''Trabeculae & eErythrocytes (rat)'''</p><sup>©RVC 2008</sup>
Image:LH_Spleen_Rat_Higher_4_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup></gallery>
Image:LH_Spleen_Mouse_Higher_Histology.jpg|<p>'''Megakaryocyte & macrophages (mouse)'''</p><sup>©RVC 2008</sup></gallery>
Image:LH_Spleen_Mouse_Higher_Histology.jpg|<p>''' '''</p><sup>©RVC 2008</sup>
==Functions==
==Functions==