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<p>To enter circulation newly formed cells press against the sinusoid wall, temporally fusing to it and creating an opening. The cell then passes directly into the circulation and the membrane repairs itself. Mature [[erythrocytes]] immediately enter circulation, however the marrow stores leukocytes and consequently contains around ten times more [[Leukocytes - Anatomy & Physiology|leukocytes]] than found in circulation</p>
<p>To enter circulation newly formed cells press against the sinusoid wall, temporally fusing to it and creating an opening. The cell then passes directly into the circulation and the membrane repairs itself. Mature [[erythrocytes]] immediately enter circulation, however the marrow stores leukocytes and consequently contains around ten times more [[Leukocytes - Anatomy & Physiology|leukocytes]] than found in circulation</p>
<p>[[Thrombopoiesis - Anatomy & Physiology#Megakaryocyte|Megakaryocytes]] residue alongside the sinusoid membrane but do not leave the tissue, rather they release their platelets and then withdraw from the membrane.</p>
<p>[[Thrombopoiesis - Anatomy & Physiology#Megakaryocyte|Megakaryocytes]] residue alongside the sinusoid membrane but do not leave the tissue, rather they release their platelets and then withdraw from the membrane.</p>
===Lymphoid tissue===
*In some primates it acts as a [[Primary Lymphoid Tissue - Anatomy & Physiology|primary lymphoid organ]]
*Bone marrow is also a [[Secondary Lymphoid Tissue - Anatomy & Physiology|secondary lympoid tissue]]
**By mass the largest
<p>It has little involvement in the primary immune response, but the migration of [[B cell differentiation- Anatomy & Physiology#Memory cells|memory cells]] into the marrow from the [[Spleen - Anatomy & Physiology|spleen]] and [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] means that during a subsequent exposure to an antigen it produces significant amounts of antibodies.</p>
===Others===
===Others===
*It is a significant source of antibodies as a large population of antibody-producing cells ([[B cell differentiation- Anatomy & Physiology#Plasma cells|plasma cells]]) reside in the bone marrow
*It is a significant source of antibodies as a large population of antibody-producing cells ([[B cell differentiation- Anatomy & Physiology#Plasma cells|plasma cells]]) reside in the bone marrow
*[[Macrophages - Anatomy & Physiology|Macrophages]] and dendritic cells in the marrow remove foreign substance from the blood
*[[Macrophages - Anatomy & Physiology|Macrophages]] and dendritic cells in the marrow remove foreign substance from the blood
**A process which also occurs in the [[Lymph nodes - Anatomy & Physiology|lymph nodes]], [[Spleen - Anatomy & Physiology|spleen]] and [[Liver - Anatomy & Physiology#Functions|liver ]]
**A process which also occurs in the [[Lymph nodes - Anatomy & Physiology|lymph nodes]], [[Spleen - Anatomy & Physiology|spleen]] and [[Liver - Anatomy & Physiology#Functions|liver]]
==In pathology==
==In pathology==
*[[Lymphoreticular/Haemotopoietic System - Bone Marrow#Pathology|See here]]
*[[Lymphoreticular/Haemotopoietic System - Bone Marrow#Pathology|See here]]