Changes

Serum phosphorus is closely related to the serum calcium concentration. It is primarily regulated through the action of parathyroid hormone and calcitonin providing a dual negative feedback control mechanism to regulate calcium homeostasis, by acting on target cells in the bone and kidney and indirectly, the intestine. Serum concentration is regulated by renal excretion under the influence of parathyroid hormone. In patients with decreased glomerular filtration rate concentrations will rise due to reduced clearance. Abnormal levels are caused by variations in dietary intake, decreased renal excretion, drug therapy (diuretics, salicylates and phosphate containing enemas) and the hormonal imbalances that affect serum calcium. Translocation between the intracellular and extracellular compartment is governed by similar factors to potassium, hence an intracellular shift is promoted by insulin, alkalosis and glucose infusion.

Serum phosphorus is closely related to the serum calcium concentration. It is primarily regulated through the action of parathyroid hormone and calcitonin providing a dual negative feedback control mechanism to regulate calcium homeostasis, by acting on target cells in the bone and kidney and indirectly, the intestine. Serum concentration is regulated by renal excretion under the influence of parathyroid hormone. In patients with decreased glomerular filtration rate concentrations will rise due to reduced clearance. Abnormal levels are caused by variations in dietary intake, decreased renal excretion, drug therapy (diuretics, salicylates and phosphate containing enemas) and the hormonal imbalances that affect serum calcium. Translocation between the intracellular and extracellular compartment is governed by similar factors to potassium, hence an intracellular shift is promoted by insulin, alkalosis and glucose infusion.