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T cell differentiation (view source)

Revision as of 11:00, 22 August 2008

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<big><center>[[Immunology - WikiBlood|'''BACK TO IMMUNOLOGY''']]</center></big>
 
<big><center>[[Immunology - WikiBlood|'''BACK TO IMMUNOLOGY''']]</center></big>
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==
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==Development of CD4+ T-Cell Subpopulations==
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===Development of CD4+ T-Cell Subpopulations===
      
* Within the blood and lymphoid organs the majority of CD4+ T cells are antigen-naive T-cells.
 
* Within the blood and lymphoid organs the majority of CD4+ T cells are antigen-naive T-cells.
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* The proliferation of T cells continues until antigen disappears.
 
* The proliferation of T cells continues until antigen disappears.
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===TH<sub>1</sub> Cells===
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==TH<sub>1</sub> Cells==
    
* TH<sub>1</sub> cells secrete a range of cytokines.
 
* TH<sub>1</sub> cells secrete a range of cytokines.
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*** Can act to suppress antibody synthesis.
 
*** Can act to suppress antibody synthesis.
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===TH<sub>2</sub> Cells===
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==TH<sub>2</sub> Cells==
    
* The TH2 population influences B-cell activation, proliferation and immunoglobulin production.
 
* The TH2 population influences B-cell activation, proliferation and immunoglobulin production.
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*** Promotes immunoglobulin synthesis.
 
*** Promotes immunoglobulin synthesis.
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===Common Functions of Th<sub>1</sub> and TH<sub>2</sub> Cells===
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==Common Functions of Th<sub>1</sub> and TH<sub>2</sub> Cells==
    
* Both TH1 and TH2 cells produce IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF).  
 
* Both TH1 and TH2 cells produce IL-3 and granulocyte-macrophage colony stimulating factor (GM-CSF).  
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