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Glomerular Apparatus and Filtration - Anatomy & Physiology (view source)
Revision as of 17:30, 4 September 2008
, 17:30, 4 September 2008→Physiological Regulators of GFR
'''[[The Effects of Nitrous Oxide and Prostaglandins on GFR - Anatomy & Physiology|Nitrous Oxide and Prostaglandins]]'''
'''[[The Effects of Nitrous Oxide and Prostaglandins on GFR - Anatomy & Physiology|Nitrous Oxide and Prostaglandins]]'''
==Pressure in the Peritubular Capillaries==
The peritubular capillaries have a lower hydrostatic pressure and a higher protein osmotic pressure than the rest of the capillaries in the body. This is largely thanks to the fact that the blood within them has had a substantial quantity of its plasma removed by the [[Glomerulus and Bowmans Capsule - Anatomy & Physiology | Glomerulus]]. Resulting in a low concentration of solutes but a high concentration of protein. These pressures however are not constant and changes in them affect reabsorption. They have the biggest effect in the '''proximal tubule''' thanks to the relatively weaker tight junctions which allow water and ions to pass paracellulary.
===The Effects of Changing Pressure===
If hydrostatic pressure is elevated and protein osmotic pressure reduced then water leaves the Interstium and enters the tubular lumen thus increasing water loss. These pressure changes are characteristic of a situation where the animal drinks a large amount of water in a short period of time.
If the situation is reversed it results in a decreased urinary output and is often caused by a fall in blood pressure associated with a reduction in ECF.
==Renal Clearance==
==Renal Clearance==