* The sensitivity of the surge centre never changes. Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases. This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate follicles, so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH. | * The sensitivity of the surge centre never changes. Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases. This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate follicles, so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH. |