Line 41: Line 41:  
* Increased amounts of GnRH lead to increased LH and FSH, which results in higher oestrogen production by the [[Female_Reproductive_Tract_-The_Ovary_-_Anatomy_%26_Physiology|ovaries]].
 
* Increased amounts of GnRH lead to increased LH and FSH, which results in higher oestrogen production by the [[Female_Reproductive_Tract_-The_Ovary_-_Anatomy_%26_Physiology|ovaries]].
 
* When oestrogen levels reach a certain threshold, the surge centre is triggered by positive feedback.  This results in a massive discharge of GnRH.
 
* When oestrogen levels reach a certain threshold, the surge centre is triggered by positive feedback.  This results in a massive discharge of GnRH.
* This causes a surge in LH, so ovulation can occur and puberty ensues.
+
* This causes a surge in LH, so [[The_Ovary_-_Ovulation_-_Anatomy_%26_Physiology|ovulation]] can occur and puberty ensues.
 
* The sensitivity of the surge centre never changes.  Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases.  This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate follicles, so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH.
 
* The sensitivity of the surge centre never changes.  Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases.  This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate follicles, so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH.
  
4,503

edits