Changes

* The tonic GnRH centre stimulates LH pulses from the [[Pituitary_Gland_-_Anatomy_%26_Physiology#Anterior_Pituitary_Gland|Anterior Pituitary Gland]]. The amplitude of these pulses is the same as in the post-pubertal female, but the frequency is much lower.

* The tonic GnRH centre stimulates LH pulses from the [[Pituitary_Gland_-_Anatomy_%26_Physiology#Anterior_Pituitary_Gland|Anterior Pituitary Gland]]. The amplitude of these pulses is the same as in the post-pubertal female, but the frequency is much lower.

* Prior to puberty, low frequency GnRH pulses do not provide enough stimulus for the [[Pituitary_Gland_-_Anatomy_%26_Physiology#Anterior_Pituitary_Gland|Anterior Pituitary Gland]] to release FSH and LH at high levels.

* Prior to puberty, low frequency GnRH pulses do not provide enough stimulus for the [[Pituitary_Gland_-_Anatomy_%26_Physiology#Anterior_Pituitary_Gland|Anterior Pituitary Gland]] to release FSH and LH at high levels.

* Therefore, follicular development does not result in high levels of circulating oestradiol.

* Therefore, [[The_Ovary_-_Follicles_-_Anatomy_%26_Physiology|follicular development]] does not result in high levels of circulating oestradiol.

* Oestradiol remains below the threshold that is needed to trigger the GnRH surge centre.

* Oestradiol remains below the threshold that is needed to trigger the GnRH surge centre.

* The secretion of GnRH from the surge centre neurons is controlled by both positive and negative feedback.

* The secretion of GnRH from the surge centre neurons is controlled by both positive and negative feedback.

* The surge centre and the tonic centre in the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]] are anatomically distinct from one another.

* The surge centre and the tonic centre in the [[Hypothalamus_-_Anatomy_%26_Physiology|Hypothalamus]] are anatomically distinct from one another.

* The surge centre responds primarily to positive feedback stimulus.

* The surge centre responds primarily to positive feedback stimulus.

* In the pre-pubertal female, the sensitivity of the surge centre to the positive feedback of oestrogen is quite high, but ovlation does not occur.  This is because the immature [[Female_Reproductive_Tract_-The_Ovary_-_Anatomy_%26_Physiology|ovaries]] do not produce enough oestrogen to activate the highly sensitive surge centre.

* In the pre-pubertal female, the sensitivity of the surge centre to the positive feedback of oestrogen is quite high, but [[The_Ovary_-_Ovulation_-_Anatomy_%26_Physiology|ovulation]] does not occur.  This is because the immature [[Female_Reproductive_Tract_-The_Ovary_-_Anatomy_%26_Physiology|ovaries]] do not produce enough oestrogen to activate the highly sensitive surge centre.

* At these low levels of oestrogen, the tonic centre has high sensitivity to negative feedback stimulus, therefore it does not produce high levels of GnRH so LH and FSH levels also remain low.

* At these low levels of oestrogen, the tonic centre has high sensitivity to negative feedback stimulus, therefore it does not produce high levels of GnRH so LH and FSH levels also remain low.

* During the approach to puberty, the sensitivity of the tonic centre to negative feedback decreases, allowing increasing amounts of GnRH to be produced.

* During the approach to puberty, the sensitivity of the tonic centre to negative feedback decreases, allowing increasing amounts of GnRH to be produced.

* When oestrogen levels reach a certain threshold, the surge centre is triggered by positive feedback.  This results in a massive discharge of GnRH.

* When oestrogen levels reach a certain threshold, the surge centre is triggered by positive feedback.  This results in a massive discharge of GnRH.

* This causes a surge in LH, so [[The_Ovary_-_Ovulation_-_Anatomy_%26_Physiology|ovulation]] can occur and puberty ensues.

* This causes a surge in LH, so [[The_Ovary_-_Ovulation_-_Anatomy_%26_Physiology|ovulation]] can occur and puberty ensues.

* The sensitivity of the surge centre never changes.  Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases.  This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate follicles, so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH.

* The sensitivity of the surge centre never changes.  Puberty is triggered because the sensitivity of the tonic centre to negative feedback decreases.  This allows smaller quantities of oestrogen to stimulate the release of GnRH and thus LH and FSH. These gonadotrophins then stimulate [[The_Ovary_-_Follicles_-_Anatomy_%26_Physiology|follicles]], so that more and more oestrogen is produced until it is sufficient to trigger the surge centre to release the pre-ovulatory surge of GnRH.

== Male ==

== Male ==