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Special:MobileDiff/35553
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Major Histocompatability Complexes
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Revision as of 13:25, 9 September 2008
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13:25, 9 September 2008
→The Genetics of the MHC (Polymorphism)
Line 111:
Line 111:
**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
**Most polymorphic regions of class II are in the alpha 1 and beta 1 domains
*Most polymorphisms are point mutations
*Most polymorphisms are point mutations
−
* There are millions of variations in antibodies and TCR
+
* There are millions of variations in
[[Immunoglobulins - WikiBlood|
antibodies
]]
and TCR
** However, with MHC there is very limited variation between molecules
** However, with MHC there is very limited variation between molecules
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft
*Allelic variation within the MHC molecule occurs at the peptide binding site and on the top or sides of the binding cleft
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