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==Side Effects and Contraindications==
 
==Side Effects and Contraindications==
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This group of antibiotics on the whole are very safe.
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* It has been known to cause acute anaphylaxis or mild hypersensitive reactions.
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* High intravenous doses can lead to platelet dysfunction.
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* Penicillins containing procaine musn't be given I.V. or with sulphonamides (they antagonise the action of sulphonamides.)
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* Care must be taken when giving narrow spectrum penicillins to Guinea Pigs, Rabbits, Gerbils, Hamsters and Chinchillas as they can result in '''fatal ''Clostridium difficile'' colitis'''.
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