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→Side Effects and Contraindications
==Side Effects and Contraindications==
==Side Effects and Contraindications==
Major reactions to sulphonamides are uncommon but the following are the most common of the side effects recorded:
* Rapid intravenous injection can lead to muscle weakness, ataxia and collapse. This has only been recorded in cattle and horses.
* They can precipitate in tubular fluid resulting in renal tubular damage.
* Dobermans have had serious allergic reactions to them including immune-mediated polyarthritis, thrombocytopenia and haemolytic anaemia.
* Severe hepatotoxicity has been noted in some dogs.
* Long dosage regimens of Sulphonamides have resulted in keratoconjunctivitis sica/'dry eye' in dogs.
* Sulphonamides inhibit thyroid gland function and so mild signs of hypothyroidism have been seen in dogs that have had intesive dosage regimens.