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→Side Effects and Contraindications
===Side Effects and Contraindications===
===Side Effects and Contraindications===
* They tend to be nephrotoxic and shouldn't be used if any renal pathology is suspected. To try and avoid this problem give one large single dose daily rather than splitting the dose up as accumulation of the drug will be increased in the kidney.
* Ototoxicity is a problem with the Vestibulocochlear Nerve (Cranial Nerve VIII) affected.
* They can create non-depolarising neuromuscular junction blocks leading to acute paralysis and cardiovascular collapse if given intravenously.