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New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |sublink1=Parvoviridae |subtext1=PARVOVIRUSES |pagetype =Bugs }} <br> ====Antigenicity==== *2 Canine Viruses: **Canine Parv...
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{{toplink
|linkpage =Viruses
|linktext =VIRUSES
|sublink1=Parvoviridae
|subtext1=PARVOVIRUSES
|pagetype =Bugs
}}
<br>
====Antigenicity====
*2 Canine Viruses:
**Canine Parvovirus 1 ('''CPV1'''): avirulent, ubiquitous in canine population
**Canine Parvovirus 2 ('''CPV2'''): new virus emerged in the late 1970's
*Antigenic variants occur
====Hosts====
*Dogs
*CPV 2a/2b can cause disease in cats
====Pathogenesis====
*Oropharyngeal infection followed by '''viremia'''
*2 distinct syndromes:
*#'''Myocarditis''' in puppies aged 3-8 weeks
***Virus targets rapidly dividing myocardium
***Sudden death, '''fading puppy''' syndrome
***Now rare due to widespread passive immunity
*#'''Enteritis''' in puppies >8 weeks of age
***Virus targets intestinal crypts
***Villi shorten, then destruction of cypt cells
***Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis
***High morbidity, low mortality (10%)
====Epidemiology====
*'''Orofecal''' transmission
*Host range is controlled by only a few amino acids
====Diagnosis====
*HA or ELISA for virus
====Control====
*Vaccination, usually in combination with distemper and hepatitis at 10 and 16 weeks of age
*Thorough disinfection after disease
{{toplink
|linkpage =Viruses
|linktext =VIRUSES
|sublink1=Parvoviridae
|subtext1=PARVOVIRUSES
|pagetype =Bugs
}}
<br>
====Antigenicity====
*2 Canine Viruses:
**Canine Parvovirus 1 ('''CPV1'''): avirulent, ubiquitous in canine population
**Canine Parvovirus 2 ('''CPV2'''): new virus emerged in the late 1970's
*Antigenic variants occur
====Hosts====
*Dogs
*CPV 2a/2b can cause disease in cats
====Pathogenesis====
*Oropharyngeal infection followed by '''viremia'''
*2 distinct syndromes:
*#'''Myocarditis''' in puppies aged 3-8 weeks
***Virus targets rapidly dividing myocardium
***Sudden death, '''fading puppy''' syndrome
***Now rare due to widespread passive immunity
*#'''Enteritis''' in puppies >8 weeks of age
***Virus targets intestinal crypts
***Villi shorten, then destruction of cypt cells
***Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis
***High morbidity, low mortality (10%)
====Epidemiology====
*'''Orofecal''' transmission
*Host range is controlled by only a few amino acids
====Diagnosis====
*HA or ELISA for virus
====Control====
*Vaccination, usually in combination with distemper and hepatitis at 10 and 16 weeks of age
*Thorough disinfection after disease