Changes

* A non-infectious [[CNS Inflammation - Pathology|central nervous inflammatory disease]]

* A non-infectious [[CNS Inflammation - Pathology|central nervous inflammatory disease]]

* Polyneuritis equi (PNE) is an uncommon disease which affects mature horses

* Polyneuritis equi (PNE) is an uncommon disease which affects mature horses

* Formerly known as 'cauda equina syndrome' or 'cauda equine neuritis'

* Formerly known as 'cauda equina syndrome' or 'cauda equina neuritis'

* May occur as:

* May occur as:

** A disease effecting the spinal nerve roots and ganglia of the cauda equina.

** A disease effecting the spinal nerve roots and ganglia of the cauda equina.

** Protein is usually elveated.

** Protein is usually elveated.

* Histologically, the disease presents as a severe, chronic, destructive lymphocytic and histiocytic polyradiculoneuritis.

* Histologically, the disease presents as a severe, chronic, destructive lymphocytic and histiocytic polyradiculoneuritis.

* Considered to be caused by a T-lymphocyte mediated response to myelin, followed by destruction of myelin and axons by macrophages

* Pathogenesis not completely understood, but considered to be caused by a T-lymphocyte mediated response to myelin, followed by destruction of myelin and axons by macrophages

* Disease appears similar to:

* Disease appears similar to:

** Guillain-Barré Syndrome (GBS), an autoimmune demyelinating diease in humans

** Guillain-Barré Syndrome (GBS), an autoimmune demyelinating diease in humans

** Sacral/coccygeal trauma

** Sacral/coccygeal trauma

** Equine motor neuron disease

** Equine motor neuron disease

** Abberant parasite migration (e.g. ''Strongylus'')

** Abberant parasite migration (e.g. ''Strongylus spp.'')

** In endemic areas, ''Sarcocystis neurona'' myelitis (equine protozoal myelitis), rabies and ''rhodococcus equi'' myeloencepahlitis should also be considered.

** In endemic areas, ''Sarcocystis neurona'' myelitis (equine protozoal myelitis), rabies and ''rhodococcus equi'' myeloencepahlitis should also be considered.