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*Capsular polysaccharides produced by some strains prevent phagocytosis and interfere with complement
 
*Capsular polysaccharides produced by some strains prevent phagocytosis and interfere with complement
 
*Endotoxin is a lipolysaccharide component of the cell wall of Gram-negative bacteria, composed of lipid A, a core polysaccharide and various side chains
 
*Endotoxin is a lipolysaccharide component of the cell wall of Gram-negative bacteria, composed of lipid A, a core polysaccharide and various side chains
*'''Endotoxin''' is realeased when bacteria die, and causes endothelial damage leading to [[General Pathology - Thrombosis#Disseminated Intravascular Coagulation|'''disseminated intravascular coagulation''']] and e'''ndotoxic shock'''; it is also a '''pyrogen'''
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*'''Endotoxin''' is realeased when bacteria die, and causes endothelial damage leading to [[Thrombosis - Pathology#Disseminated Intravascular Coagulation|'''disseminated intravascular coagulation''']] and e'''ndotoxic shock'''; it is also a '''pyrogen'''
 
*Enterotoxins, verotoxins and cytotoxic necrotising factors produced by many pathogenic ''E. coli''; these produce cell damage at their site of action
 
*Enterotoxins, verotoxins and cytotoxic necrotising factors produced by many pathogenic ''E. coli''; these produce cell damage at their site of action
 
*'''Alpha-haemolysin''' may increase iron availability for invading organisms
 
*'''Alpha-haemolysin''' may increase iron availability for invading organisms
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*''E. coli'' is part of the flora of the large intestine, but is not usually found in the small intestine
 
*''E. coli'' is part of the flora of the large intestine, but is not usually found in the small intestine
 
*Some strains possess fimbrae which attach the bacteria to the small intestinal epithelium of particular animal species
 
*Some strains possess fimbrae which attach the bacteria to the small intestinal epithelium of particular animal species
*''E. coli'' may cause diarrhoea via attaching and effacing lesions, where bacteria adhere intimately to the enterocyte, and cause localised effacement of the brush border microvilli; the epithelial erosion causes [[General Pathology - Haemorrhage#Dysentery|dysentery]]
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*''E. coli'' may cause diarrhoea via attaching and effacing lesions, where bacteria adhere intimately to the enterocyte, and cause localised effacement of the brush border microvilli; the epithelial erosion causes [[Haemorrhage - Pathology#Dysentery|dysentery]]
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**Strains do not product LT or ST and are not enteroinvasive
 
**Strains do not product LT or ST and are not enteroinvasive
 
**Attaching and effacing lesions, unrelated to toxin production
 
**Attaching and effacing lesions, unrelated to toxin production
**[[General Pathology - Thrombosis#Disseminated Intravascular Coagulation|Disseminated intravascular coagulation]] and thrombus formation  
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**[[Thrombosis - Pathology#Disseminated Intravascular Coagulation|Disseminated intravascular coagulation]] and thrombus formation  
 
**''E. coli'' O157:H7 causes haemorrhagic collitis-haemolytic uraemic syndrome in humans
 
**''E. coli'' O157:H7 causes haemorrhagic collitis-haemolytic uraemic syndrome in humans