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[[Image:meninges.jpg|thumb|right|150px|Diagram of the meninges. Sourced from WikiMedia Commons, attributed to [http://training.seer.cancer.gov/module_anatomy/unit5_3_nerve_org1_cns.html http://training.seer.cancer.gov/module_anatomy/unit5_3_nerve_org1_cns.html]]]
* The CNS is surrounded by several layers of tissue.
*# Bone layer
*#* E.g. the skull and the vertebrae.
*# Dura-arachnoid layer.
*#* Composed of the dura mater and arachnoid layer in close opposition.
*#* Adhered to the skull in the calvaria.
*# Pia mater.
* The '''epidural space''' lies between the bone layer (skull or vertebrae) and the dura-arachnoid layer.
** Local anaesthetic is injected here in epidural anaesthesia.
*** E.g. when calving cows.
* The '''sub-arachnoid space''' lies between the arachnoid layer and the pia mater.
** CSF filled.
** This is where myelographic contrast medium is injected.