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Category:Oral Cavity - Vesicular Pathology (view source)
Revision as of 12:10, 25 May 2010
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}}[[Category:Oral_Cavity_and_Gingiva_-_Pathology]]
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===Pathology===
*Damage to prickle cells (stratum spinosum).
*Appears as accumulation of fluid within epithelium, quickly erodes leaving hyperaemic [[stratum germinativum]].
*Heals by proliferation of new cells, so long as infection does not continue.
===Pathogenesis===
May be caused by:
#Ingestion of hot food (corrosive liquids)
#Systemic viral diseases. ''e.g'':
##[[Foot and Mouth Disease Virus|Foot and Mouth disease]] - ruminants and pigs
##[[Vesicular stomatitis]] - horse, pigs, cattle
##[[Vesicular exanthema]] - pigs
N.B. All are indistinguishable from FMD clinically.
===[[Foot and Mouth Disease (FMDV)]]===
====Pathology====
=====Gross=====
#Initially - hyperaemia of mucosa (e.g. catarrhal inflammation) then within 12 hours produces fluid filled vesicles on dorsum of [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]], may be other places
#Small vesicle coalesce to produce big ones -i.e. Bullae
#Very quickly rupture; epithelium appears dirty grey in colour because of necrosis - sloughed skin, very good for diagnosis
#Leave painful, hyperaemic epithelium
#Looks like "ulcer "with ragged edge but not a true ulcer as stratum germinativum retained and will rapidly heal completely in about 2 weeks unless becomes secondarily infected
=====Microscopic lesions=====
*Degeneration of prickle cells
*Cells "balloon" as fill with fluid and then die to produce vesicle containing straw coloured or clear fluid
===[[Swine Vesicular Disease]]===
*May produce vesicles in mouth that are indistinguishable from foot and mouth disease
*Swine vesicular disease produces sporadic large outbreaks
**Approximately 5% have lesions in mouth, foot lesions much more common
===Vesicles in dogs===
*Vesicles in mouth are often caused by hot food - especially in dogs.
*Can produce quite big vesicles, but will heal.
*No major problems associated with vesicles on [[Oral Cavity - Tongue - Anatomy & Physiology|tongue]] in dogs (except if due to drinking battery acid, but this also produces vomiting).
[[Category:Oral_Cavity_and_Gingiva_-_Pathology]]