Changes

Category:Enteritis, Villus Atrophy (view source)

662 bytes removed , 11:05, 6 June 2010

no edit summary

Line 9: Line 9:

−

===Villus atrophy with damage to crypts===

+

===[[Villus atrophy with damage to crypts]]===

−

* The primary insult is to crypt cells.

+

−

** Crypt cell death leads to dilated gland lumens (cysts).

−

** Production is impaired, eventually leading to insufficient cells for villi.

−

* Enterocytes lost to lumen are replaced by increasingly immature cells.

−

** Gives rise to severe malabsorption.

−

* If damage is severe, erosions/ulcers may form which may eventually heal.

−

** Even if there are no ulcers, damage can be long-term

−

*** Causes long-term malabsorption.

−

* Examples include:

−

** '''Parvovirus'''

−

*** Target crypt cells.

−

** '''Lymphoma'''

−

*** Numerous neoplastic lymphocytes compress crypts.

−

** '''Cytotoxic chemicals'''

−

*** Dividing crypt cells are susceptible.

==Enteritis Particularly Associated with Villus Atrophy==

53,803

edits