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===Villus atrophy with damage to crypts===
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===[[Villus atrophy with damage to crypts]]===
 
   
 
   
* The primary insult is to crypt cells.
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** Crypt cell death leads to dilated gland lumens (cysts).
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** Production is impaired, eventually leading to insufficient cells for villi. 
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* Enterocytes lost to lumen are replaced by increasingly immature cells.
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** Gives rise to severe malabsorption.
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* If damage is severe, erosions/ulcers may form which may eventually heal.
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** Even if there are no ulcers, damage can be long-term
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*** Causes long-term malabsorption.
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* Examples include:
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** '''Parvovirus'''
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*** Target crypt cells.
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** '''Lymphoma'''
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*** Numerous neoplastic lymphocytes compress crypts.
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** '''Cytotoxic chemicals'''
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*** Dividing crypt cells are susceptible.
      
==Enteritis Particularly Associated with Villus Atrophy==
 
==Enteritis Particularly Associated with Villus Atrophy==
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