Changes

*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]

*Neutropenia every 2 weeks which lasts 3-4 days due to cyclic production of cells from [[Bone Marrow - Anatomy & Physiology|bone marrow]]

*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract  

*Animals are prone to recurrent infections, mainly from the respiratory and gastrointestinal tract  

**E.g. pyrexia, [[Intestine Diarrhoea - Pathology|diarrhoea]], gingivitis and arthritis

**E.g. pyrexia, [[Diarrhoea|diarrhoea]], gingivitis and arthritis

*Puppies can be distinguished from other litter mates by the diluted grey colouring

*Puppies can be distinguished from other litter mates by the diluted grey colouring

*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age

*Affected puppies show symptoms such as fever, joint pain and eye, skin and respiratory infections from 8 weeks of age