*there is substantial necrosis of the [[Liver - Anatomy & Physiology|liver]] tissue even though it may not be pronounced on gross inspection
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*there is contact of blood with the damaged [[Liver - Anatomy & Physiology|liver]] parenchyma which triggers the clotting cascade, consuming the circulating clotting factors - have a short half life
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*since the [[Liver - Anatomy & Physiology|liver]] is also responsible for the production of these clotting factors, there is an acute shortage and an animal dying from such acute [[Liver - Anatomy & Physiology|liver]] damage may show petechial and ecchymotic haemorrhages in many organs of the body
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*see Canine Viral Hepatitis (ICH)
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**gross and microscopic appearances - haemorrhages will be seen in many tissues in this disease, particularly on the intestinal serosa