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Category:Liver - Storage Diseases (view source)
Revision as of 13:30, 7 June 2010
, 13:30, 7 June 2010Created page with '==Lysosomal Storage Disease== ==Amyloidosis== *amyloid infiltration occurs in all species *an inert substance deposited under the endothelium and basement membranes of a var…'
==[[Lysosomal Storage Disease]]==
==Amyloidosis==
*amyloid infiltration occurs in all species
*an inert substance deposited under the endothelium and basement membranes of a variety of tissues
**renal glomeruli
**[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]]
**[[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords)
====Causes====
May be a primary condition or appear secondary to some chronic tissue destructive process
*an infectious process elsewhere in the body
*a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes
====Gross====
*pale (greyish waxy appearance)
*enlarged
*rounded edges
*firm
*very prone to rupture
====Microscopically====
*deposition of amyloid in the space of Disse
*shows 'apple-green' fluorescence under polarised light after staining with Congo Red
[[Category:Liver_-_Pathology]]
==Amyloidosis==
*amyloid infiltration occurs in all species
*an inert substance deposited under the endothelium and basement membranes of a variety of tissues
**renal glomeruli
**[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]]
**[[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords)
====Causes====
May be a primary condition or appear secondary to some chronic tissue destructive process
*an infectious process elsewhere in the body
*a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes
====Gross====
*pale (greyish waxy appearance)
*enlarged
*rounded edges
*firm
*very prone to rupture
====Microscopically====
*deposition of amyloid in the space of Disse
*shows 'apple-green' fluorescence under polarised light after staining with Congo Red
[[Category:Liver_-_Pathology]]