Changes

*In mucosal B cells plasma cells CD40 interaction (with Th2 CD40L) and Il-10 stimulates class switching to [[Immunoglobulin A|IgA]]

*In mucosal B cells plasma cells CD40 interaction (with Th2 CD40L) and Il-10 stimulates class switching to [[Immunoglobulin A|IgA]]

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E - WikiBlood|IgE]]</p>

*[[Eosinophils|Eosinophils]] produce Il-13 which promotes class switching to [[Immunoglobulin E - WikiBlood|IgE]]</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G - WikiBlood|IgG]] class.</p>

<p>Plasma cells produced in the first immune response to an antigen are mainly of the class IgM whereas those produced from memory cells in the second immune response are mainly of the [[Immunoglobulin G|IgG]] class.</p>

<p>For more information on class switching click [[Immunoglobulins#Immunoglobulin Class Switching|here]]</p>

<p>For more information on class switching click [[Immunoglobulins#Immunoglobulin Class Switching|here]]</p>

*The log phase will peak after about 10-14 days

*The log phase will peak after about 10-14 days

*The '''Plateau Phase''' will then occur

*The '''Plateau Phase''' will then occur

*[[Immunoglobulins#Immunoglobulin Class Switching|Class switching]] occurs replacing decresing levels of [[Immunoglobulin M - WikiBlood|IgM]] with [[Immunoglobulin G - WikiBlood|IgG]]

*[[Immunoglobulins#Immunoglobulin Class Switching|Class switching]] occurs replacing decresing levels of [[Immunoglobulin M - WikiBlood|IgM]] with [[Immunoglobulin G|IgG]]

*Antibody levels will then begin to decline as plasma cells undergo apoptosis

*Antibody levels will then begin to decline as plasma cells undergo apoptosis

*After primary immunisation, it usually takes around 7-10 days for a measurable antibody response to become detectable  

*After primary immunisation, it usually takes around 7-10 days for a measurable antibody response to become detectable  

*  The first antibody to be produced in any immune response is [[Immunoglobulin M - WikiBlood|IgM]]

*  The first antibody to be produced in any immune response is [[Immunoglobulin M - WikiBlood|IgM]]

** This is because the gene that codes the constant domain of [[Immunoglobulin M - WikiBlood|IgM]] (Cμ) is directly downstream to the genes that code the variable antibody domain

** This is because the gene that codes the constant domain of [[Immunoglobulin M - WikiBlood|IgM]] (Cμ) is directly downstream to the genes that code the variable antibody domain

* During primary response, [[Immunoglobulin G - WikiBlood|IgG]] production  lags about a week behind that of [[Immunoglobulin M - WikiBlood|IgM]]

* During primary response, [[Immunoglobulin G|IgG]] production  lags about a week behind that of [[Immunoglobulin M - WikiBlood|IgM]]

====Secondary T Cell Dependent Response====

====Secondary T Cell Dependent Response====

** Can stimulate the immune system for years

** Can stimulate the immune system for years

* The level of [[Immunoglobulin M - WikiBlood|IgM]] antibody production is similar to the primary response

* The level of [[Immunoglobulin M - WikiBlood|IgM]] antibody production is similar to the primary response

* The increase in antibody production occurs with [[Immunoglobulin G - WikiBlood|IgG]]

* The increase in antibody production occurs with [[Immunoglobulin G|IgG]]