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Feline Herpesvirus 1 (view source)

Revision as of 10:55, 30 June 2010

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*Killed and live '''vaccines''' are available

**Live vaccines have provoked symptoms in immunosuppressed kittens and are no longer used in the UK

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===Feline viral rhinotracheitis===

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*Caused by a [[Herpesviridae|herpesvirus]]

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*Tends to be more [[Nasal Cavity Inflammatory - Pathology#Infectious causes of rhinitis|rhinitis]] than [[Trachea Inflammatory - Pathology#Infectious causes of tracheitis|tracheitis]], may extend to [[Paranasal Sinuses Inflammatory - Pathology#Infectious causes of sinusitis|sinusitis]]

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*Feline herpesvirus -1

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**One of the causes of Feline viral rhinotracheitis

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***Viruses and bacteria are involved in the complex. The most frequent aetiologic agent is [[Herpesviridae|FHV-1]], and less frequently [[Caliciviridae|feline calicivirus]] and/or ''[[Chlamydophila psittaci]]'' (NB: previously called ''Chlamydia psittaci'' var felis)

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*All three agents infect URT respiratory epithelium, although FHV-1 has the highest affinity for this epithelium

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*Feline calicivirus more frequently infects the oral mucosa -> ulcerative stomatitis

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*''C.psittaci'' more frequently infects the conjunctival epithelium -> chronic conjunctivitis

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*Infection of the respiratory epithelium by FHV-1 results in a typical neutrophilic rhinitis with intraepitheial intranuclear eosinophilic [[Degenerations and Infiltrations - Pathology#Cellular Inclusions|inclusion bodies]]

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*Uncomplicated cases resolve in 2-3 weeks

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*FHV-1 remains latent in the trigeminal ganglion, and can reactivate at times of stress

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*Can infect the cornea -> ulcerative keratitis

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*Mortality may be high in young kittens, debilitated and immune-suppressed animals, usually associated with secondary bacterial infection.

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[[Category:Herpesviridae]][[Category:To_Do_-_Viruses]][[Category:Cat]]

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