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Infectious Canine Hepatitis (view source)

Revision as of 15:48, 5 July 2010

183 bytes removed , 15:48, 5 July 2010

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In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.

====Gross====

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The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. ~~Fibrinous~~ or fibrino-haemorrhagic ~~strands may~~ be seen between the lobes of the liver.

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The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Ascites results from this hepatitis, and fibrinous or fibrino-haemorrhagic adhesions can sometimes be seen between the lobes of the liver.

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Other organs may also show changes. For example, the wall of the gall bladder may be oedematous, and lymph nodes can be enlarged, reddened and haemorrhagic. Chronic interstitial nephritis may feature.

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*[[Gall Bladder - Anatomy & Physiology|gall bladder]]

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**wall usually shows oedema (up to 2cm diameter)

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*[[Lymph Nodes - Anatomy & Physiology|lymph nodes]] and [[Tonsils - Anatomy & Physiology|tonsils]] are enlarged and reddened, sometimes haemorrhagic

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*Post Mortem: swollen, hemorrhagic liver, ascites, and oedema of the gall bladder

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*In older dogs, may present more mildly with lymph node enlargement and chronic interstitial nephritis

====Microscopically====

*basophilic intranuclear inclusion bodies

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