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In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.
In foxes, the virus replicates in the endothelial cells of the brain resulting in neuronal damage, fits, and paralysis.
====Gross====
====Gross====
The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Fibrinous or fibrino-haemorrhagic strands may be seen between the lobes of the liver.
The liver is enlarged and friable on post-mortem examination. Extensive centrilobular necrosis leads to a pale, mottled appearance, but widespread haemorrhage is also apparent. These haemorrhages are located particularly on the serosal surface. Ascites results from this hepatitis, and fibrinous or fibrino-haemorrhagic adhesions can sometimes be seen between the lobes of the liver.
Other organs may also show changes. For example, the wall of the gall bladder may be oedematous, and lymph nodes can be enlarged, reddened and haemorrhagic. Chronic interstitial nephritis may feature.
====Microscopically====
====Microscopically====
*basophilic intranuclear inclusion bodies
*basophilic intranuclear inclusion bodies