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| ====Differential Diagnoses==== | | ====Differential Diagnoses==== |
| + | |
| + | The disease may mimic almost any neurological disease because the parasite can localise in any region of the central nervous system (CNS).(EPM 8) |
| + | Includes virtually all diseases of the CNS (Furr) |
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| {| cellpadding="10" cellspacing="0" border="1" | | {| cellpadding="10" cellspacing="0" border="1" |
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| |PCR (Furr) | | |PCR (Furr) |
| |- | | |- |
| + | |Rabies |
| + | |Rapid progression (Sommardahl), behavioural alterations, depression, seizure, coma (Long) |
| + | |Post-mortem dx (Sommardahl) |
| + | |- |
| + | |Polyneuritis equi |
| + | |Cranial nerve deficits peripheral with no change in attitude (6 p623 in Saville) |
| + | |Western blot analysis of CSF(20 p623 in Saville) |
| + | |- |
| + | |Equine degenerative myeloencephalopathy |
| + | |Symmetrical signs (Nout, p606) |
| + | |May get increased CSF CK (3 in Nout p608) and reduced serum Vitamin E concentrations but unreliable ante mortem dx |
| + | |- |
| + | |Verminous encephalomyelitis |
| + | |Acute onset |
| + | |CSF analysis(Jose-Cunilleras) |
| + | |- |
| + | |Bacterial meningoencephalitis |
| + | |Stiff neck (Pasq) |
| | | | | |
| + | |- |
| + | |CNS abscessation (Furr) |
| | | | | |
| | | | | |
| |- | | |- |
| + | |Spinal trauma(Pasq) |
| + | |Hx (usually acute onest nuero signs), usually spolitary lesion loclaised by neuro exa (71 p589) |
| + | |Rads, myelography, CT, MRI, nuclear scintigraphy, CSF analysis, nerve conduction velocities, EMG, transcranial magnetic stimulation (p590) |
| + | |- |
| + | |Occipito-atlanto-axial malformation |
| + | |Deficits develop before 6mths (7,12, Seino) |
| | | | | |
| + | |- |
| + | |Spinal tumors |
| | | | | |
| + | |CT, MRI, definitive dx requires cytology, biopsy, histopathology, CSF analysis (Sellon) |
| + | |- |
| + | |Sorghum cystitis/ataxia (Pasq) |
| + | |Posterior ataxia or paresis, cystitis, hx of grazing Sorghum species (Talcott, ch22 |
| | | | | |
| |} | | |} |
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− | The disease may mimic almost any neurological disease because the parasite can localise in any region of the central nervous system (CNS).(EPM 8)
| |
− | Includes virtually all diseases of the CNS (Furr)
| |
− |
| |
− |
| |
− | Rabies – rapid progression (Sommardahl), behavioural alterations, depression, seizure, coma (Long), post-mortem dx (Sommardahl)
| |
− | Multifocal disease, ataxia and muscle atrophy also found with:
| |
− | Polyneuritis equi – cranial nerve deficits peripheral with no change in attitude (6 p623 in Saville), differentiate by Western blot analysis of CSF(20 p623 in Saville)
| |
− | Equine degenerative myeloencephalopathy – symmetrical signs (Nout, p606) may get increased CSF CK (3 in Nout p608) and reduced serum Vitamin E concentrations but unreliable ante mortem dx
| |
− | Changes in leukogram and CSF seen with:
| |
− | Verminous encephalomyelitis – acute onset, CSF analysis (Jose-Cunilleras)
| |
− | Bacterial meningoencephalitis - stiff neck
| |
− | CNS abscessation (Furr)
| |
| | | |
− | Spinal trauma (Pasq) – hx (usually acute onest nuero signs), usually spolitary lesion loclaised by neuro exa (71 p589) rads, myelography, CT, MRI, nuclear scintigraphy, CSF analysis, nerve conduction velocities, EMG, transcranial magnetic stimulation (p590)
| |
− | Occipito-atlanto-axial malformation – deficits develop before 6mths (7,12, Seino)
| |
| Cauda equina neuritis | | Cauda equina neuritis |
− |
| |
− | Spinal tumors – CT, MRI, definitive dx requires cytology, biopsy, histopathology, CSF analysis (Sellon)
| |
− | Sorghum cystitis/ataxia (Pasq) – posterior ataxia or paresis, cystitis, hx of grazing Sorghum species (Talcott, ch22)
| |
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| ====Prognosis==== | | ====Prognosis==== |