Changes

==Signalment==

==Signalment==

Young to middle-aged cats, 50% are under 4 years old.

Young to middle-aged cats, 50% are under 4 years old.

===Clinical Signs===

===Clinical Signs===

*History of chronic waxing and waning low-grade illness.

*History of chronic waxing and waning low-grade illness.

*Vague clinical signs which may include  

Vague clinical signs which may include anorexia, depression, weight loss, intermittent [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Diarrhoea|diarrhoea]], [[Icterus|jaundice]],lymphadenomegaly. Severe illness and pyrexia is less likely compared to [[Cholangitis, Neutrophilic]].   

**anorexia

Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

**depression

**weight loss

**intermittent [[Stomach and Abomasum Consequences of Gastric Disease - Pathology|vomiting]] and [[Diarrhoea|diarrhoea]]

**[[Icterus|jaundice]]

**lymphadenomegaly

*Severe illness and pyrexia is less likely compared to [[Cholangitis, Neutrophilic]].   

*Some cats in the UK are polyphagic and are frequently presented with ascites and/or jaundice.

===Histopathology===

===Histopathology===

Liver biopsy is important to rule out Feline Infectious Peritonitis.  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Cholangitis, Neutrophilic]] needs to be ruled out.

Liver biopsy is important to rule out [[Feline Infectious Peritonitis]]|Feline Infectious Peritonitis]] .  It is vital to obtain a haemostasis profile prior to biopsy due to risk of prolonged coagulation with liver disease.  It is unnecessary to obtain a bile sample unless the presentation is acute, in which case [[Cholangitis, Neutrophilic]] needs to be ruled out.