Changes

==Diagnosis==

==Diagnosis==

Ante-mortm diagnosis of the disease is difficult because changes are confined to the gastro-intestinal tract.  

Ante-mortem diagnosis of the disease is difficult because changes are confined to the gastro-intestinal tract.  

===Clinical signs===

===Clinical signs===

*Depression

*Depression

===Biopsy===

===Biopsy===

A definitive diagnosis is obtained by taking an ileal biopsy and inspecting the intrinsic myenteric plexus. Degenerative lesions and necrosis are seen in the autonomic nerve ganglia and enteric nervous system.   

A definitive diagnosis is obtained by taking an ileal biopsy and inspecting the intrinsic myenteric plexus. A 1-2cm eliptical biopsy should be taken from the anti-mesenteric border of the ileum at the level where the ileocaecal ligament ends. Degenerative lesions and necrosis are seen in the autonomic nerve ganglia and enteric nervous system.