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| See also:

| See also:

| '''Hyperlipaemia''' in [[Hyperlipaemia - Horse|horses]] and [[Hyperlipaemia - Donkey|donkeys]]<br>

| '''Hyperlipaemia''' in [[Hyperlipaemia- Horse|'''horses''']] and [[Hyperlipaemia - Donkey|'''donkeys''']]<br>

'''[[Fatty Liver Syndrome]]''' in cattle<br>

'''[[Fatty Liver Syndrome]]''' in '''cattle'''<br>

'''[[White Liver Disease - Ovine|White liver disease]]''' and '''[[Pregnancy Toxaemia|pregnancy toxaemia]]''' in sheep

'''[[White Liver Disease - Ovine|White liver disease]]''' and '''[[Pregnancy Toxaemia|pregnancy toxaemia]]''' in '''sheep'''

|}

|}

'''Primary or idiopathic hepatic lipidosis''' is most commonly recognised in obese indoor cats following a period of anorexia.  It is the most common hepatic disease of cats in North America but it is becoming more common in Europe.  It occurs due to the accumulation of large amounts of lipid in hepatocytes, producing an acute hepatopathy.  The mortality rate of this disease is high unless it is treated aggressively.   

'''Primary or idiopathic hepatic lipidosis''' is most commonly recognised in obese indoor cats following a period of anorexia.  It is the most common hepatic disease of cats in North America but it is becoming more common in Europe.  It occurs due to the accumulation of large amounts of lipid in hepatocytes, producing an acute hepatopathy.  The mortality rate of this disease is high unless it is treated aggressively.   

The pathogenesis includes a number of factors:

The pathogenesis involves a number of factors:

*excessive lipid mobilisation which is induced by anorexia, illness or stress.

*Excessive lipid mobilisation induced by anorexia, starvation, illness or stress.

*deficiency of dietary proteins and other nutrients, which reduces the liver's capacity to produce transport proteins and to metabolise fat.  Recognised nutrient deficiencies include arginine, carnitine, taurine and methionine.

*Deficiency of dietary proteins and other nutrients, which reduces the capacity of the liver to produce lipid transport proteins and to metabolise fat.  Recognised micronutrient deficiencies include arginine, carnitine, taurine and methionine.

*disturbances in the neurohormonal control of appetite resulting in inappropriate anorexia.

*Disturbances in the neurohormonal control of appetite resulting in inappropriate anorexia.

===Secondary Lipidosis===

===Secondary Lipidosis===

'''Secondary hepatic lipidosis''' is a neuroendocrine response in dogs and cats to other diseases for example, [[Pancreatitis - Dog and Cat|pacreatitis]], diabetes mellitus, [[Inflammatory Bowel Disease|inflammatory bowel disease]] and primary hyperlipidaemia.  Secondary hepatic lipidosis is therefore less closely correlated with obesity and be seen in normal or even thin cats.

'''Secondary hepatic lipidosis''' is a neuroendocrine response in dogs and cats to other diseases, including [[Pancreatitis - Dog and Cat|pancreatitis]], [[Diabetes Mellitus|diabetes mellitus]], [[Inflammatory Bowel Disease|inflammatory bowel disease]] and primary hypertriglyceridaemia.  Secondary hepatic lipidosis is therefore less closely associated with obesity and it may be seen in normal or even thin cats.

==Signalment==

==Signalment==

*Indoor cats are more prone to primary hepatic lipidosis.

Indoor and obese cats are more prone to the development of primary hepatic lipidosis during periods of stress or anorexia.

*Middle-aged cats are more prone.

==Diagnosis==

==Diagnosis==

*toxins absorbed from the gut interfere with many stages of triglyceride metabolism

*toxins absorbed from the gut interfere with many stages of triglyceride metabolism

[[Category:Liver_-_Degenerative_Pathology]][[Category:Cat]][[Category:Cattle]]

[[Category:Liver_-_Degenerative_Pathology]][[Category:Cat]]

 

[[Category:To_Do_-_James]]

[[Category:To_Do_-_James]]