1,406
edits
Changes
→NSAIDs
===NSAIDs===
===NSAIDs===
As in [[Gastric ulceration - all species|other species]], nonsteroidal anti-inflammatory drugs (NSAIDs)have been shown to cause gastric ulcers in horses. Typicaly this is associated with high doses or frequent administration of phenylbutazone or flunixin meglumine. However, although there is evidence to the contrary,<ref>Andrews, F.M, Reinemeyer, C.R, Longhofer, S.L (2009) Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses. ''Vet Ther'', 10(3):113-20.</ref>therapeutic doses of NSAIDs may be sufficient to induce EGUS. Other studies have suggested that suxibuzone causes significantly less ulcerogenic effects than phenylbutazone when administered orally(Monreal et al. 2004) and that combination treatment with phenylbutazone and flunixin meglumine may be more dangerous than phenylbutazone alone.(Reed et al. 2006)
As in [[Gastric Ulceration - all species|other species]], nonsteroidal anti-inflammatory drugs (NSAIDs)have been shown to cause gastric ulcers in horses. Typicaly this is associated with high doses or frequent administration of phenylbutazone or flunixin meglumine. However, although there is evidence to the contrary,<ref>Andrews, F.M, Reinemeyer, C.R, Longhofer, S.L (2009) Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses. ''Vet Ther'', 10(3):113-20.</ref>therapeutic doses of NSAIDs may be sufficient to induce EGUS. Other studies have suggested that suxibuzone causes significantly less ulcerogenic effects than phenylbutazone when administered orally(Monreal et al. 2004) and that combination treatment with phenylbutazone and flunixin meglumine may be more dangerous than phenylbutazone alone.(Reed et al. 2006)
Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been proven to cause ulcers in the glandular portion of the stomach (MacAllister et al. 1993), but in studies where primarily the squamous mucosa were studied, the same association was not evident (Hammond et al. 1986; Murray et al. 1989, 1996; McClure et al. 1999; Vatistas et al. 1999a; Rabuffo et al. 2002). (Jonssen 2006)
Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been proven to cause ulcers in the glandular portion of the stomach (MacAllister et al. 1993), but in studies where primarily the squamous mucosa were studied, the same association was not evident (Hammond et al. 1986; Murray et al. 1989, 1996; McClure et al. 1999; Vatistas et al. 1999a; Rabuffo et al. 2002). (Jonssen 2006)