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Tuberculosis - Cattle (view source)

Revision as of 10:58, 3 August 2010

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If the mycobacteria disseminated from the primary complex then lymph nodes in other regions will also be affected and there will be multiple small foci of infection on other organs.

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Microscopically there are '''epithelioid cells''', with large vesicular nuclei and pale cytoplasm and '''giant cells''', formed by the fusion of macrophages, are found at the centre of tubercles. Surrounding this there is a narrow layer of lymphocytes, mononuclear cells and plasma cells, more advanced cases show peripheral fibroplasia andcentral necrosis.

==Treatment==

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Control in many countries is centred on tuberculin testing with slaughter of reactors and movement restrictions to the premises.

Research work continues into the use of vaccination, or a cull strategy for the associated wildlife populations.

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==Prognosis==

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~~[[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous inflammation]] and tubercle formation.~~

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~~Microscopically:~~

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Epithelioid cells, with large vesicular nuclei and pale cytoplasm and giant cells, formed by the fusion of macrophages, are found at the centre of tubercles. Surrounding this there is a narrow layer of lymphocytes, mononuclear cells and plasma cells, more advanced cases show peripheral fibroplasia and central necrosis.

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~~In the respiratory form the mycobacteria are inhaled, gaining entry to the respiratory system. The organisms are phagocytosed by alveolar macrophages where they multiple and result in a characteristic~~

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......... ultimately, caseous necrosis develops and the nodule ruptures, releasing the organism and infection spreads. The cell mediated immune system produces cytotoxic T-lymphocytes which attack and destroy infected cells, leading to a type IV hypesensitivity reaction.

[[Category:Cattle]][[Category:To_Do_- lizzyk]]

[[Category:Respiratory_Bacterial_Infections]]

[[Category:zoonoses]]

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