Author, Donkey, Bureaucrats, Administrators
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** '''IL-2'''.
** '''IL-2'''.
*** Gives proliferation of both [[Lymphocytes#Helper CD4+|CD4+]] and [[Lymphocytes#Cytotoxic CD8+|CD8+ T-cells]].
*** Gives proliferation of both [[Lymphocytes#Helper CD4+|CD4+]] and [[Lymphocytes#Cytotoxic CD8+|CD8+ T-cells]].
*** This stimulation of proliferation of [[Lymphocytes#T cells|T cells]] is the main function of the TH<sub>1</sub> cell.
*** This stimulation of proliferation of [[T cells|T cells]] is the main function of the TH<sub>1</sub> cell.
** '''Interferon gamma''' ('''IFNγ''').
** '''Interferon gamma''' ('''IFNγ''').
*** Activates tissue macrophages
*** Activates tissue macrophages
*** Gives heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]].
*** Gives heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]].
*** Proliferation of basophils/ mast cells.
*** Proliferation of basophils/ mast cells.
*** Can inhibit some [[Lymphocytes#T cells|T cell]] responses.
*** Can inhibit some [[T cells|T cell]] responses.
** '''IL-5'''
** '''IL-5'''
*** Activates [[Lymphocytes#B cells|B cells]].
*** Activates [[B cells|B cells]].
*** Stimulates high rate [[Lymphocytes#B cells|B cells]] proliferation.
*** Stimulates high rate [[B cells|B cells]] proliferation.
*** Promotes immunoglobulin synthesis.
*** Promotes immunoglobulin synthesis.
*** Proliferation and differentiation of eosinophils.
*** Proliferation and differentiation of eosinophils.
** '''IL-6'''
** '''IL-6'''
*** Activates [[Lymphocytes#B cells|B cells]].
*** Activates [[B cells|B cells]].
*** Stimulates high rate [[Lymphocytes#B cells|B cell]] proliferation.
*** Stimulates high rate [[B cells|B cell]] proliferation.
*** Promotes immunoglobulin synthesis.
*** Promotes immunoglobulin synthesis.
** I.e. IFNγ but not IL-2.
** I.e. IFNγ but not IL-2.
*** The IFNγ shifts the balance of the immune response in favour of TH<sub>1</sub> cells.
*** The IFNγ shifts the balance of the immune response in favour of TH<sub>1</sub> cells.
**** There is therefore an increased level of [[Lymphocytes#T cells|T-cell]] proliferation.
**** There is therefore an increased level of [[T cells|T-cell]] proliferation.
***** The initiation of the immune response via CTL leads to the selective proliferation of CTL - enhances the main mechanism of killing of virally-infected cells.
***** The initiation of the immune response via CTL leads to the selective proliferation of CTL - enhances the main mechanism of killing of virally-infected cells.
* '''No signal 1'''
* '''No signal 1'''
** [[Lymphocytes#T cells|T cells]] is not activated as there is no antigen.
** [[T cells|T cells]] is not activated as there is no antigen.
* '''Both signal 1 and signal 2'''
* '''Both signal 1 and signal 2'''
** [[Lymphocytes#T cells|T cells]] is activated into clonal expansion.
** [[T cells|T cells]] is activated into clonal expansion.
*** Produces cytokines or becomes cytotoxic.
*** Produces cytokines or becomes cytotoxic.
** This is the response to a dangerous antigen.
** This is the response to a dangerous antigen.