108 bytes removed ,  13:55, 18 August 2010
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** '''IL-2'''.
 
** '''IL-2'''.
 
*** Gives proliferation of both [[Lymphocytes#Helper CD4+|CD4+]] and [[Lymphocytes#Cytotoxic CD8+|CD8+ T-cells]].
 
*** Gives proliferation of both [[Lymphocytes#Helper CD4+|CD4+]] and [[Lymphocytes#Cytotoxic CD8+|CD8+ T-cells]].
*** This stimulation of proliferation of [[Lymphocytes#T cells|T cells]] is the main function of the TH<sub>1</sub> cell.
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*** This stimulation of proliferation of [[T cells|T cells]] is the main function of the TH<sub>1</sub> cell.
 
** '''Interferon gamma''' ('''IFN&gamma;''').
 
** '''Interferon gamma''' ('''IFN&gamma;''').
 
*** Activates tissue macrophages  
 
*** Activates tissue macrophages  
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*** Gives heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]].
 
*** Gives heavy chain switch from [[Immunoglobulin M|IgM]] to [[Immunoglobulin G|IgG]] , [[Immunoglobulin A|IgA]] and [[Immunoglobulin E|IgE]].
 
*** Proliferation of basophils/ mast cells.  
 
*** Proliferation of basophils/ mast cells.  
*** Can inhibit some [[Lymphocytes#T cells|T cell]] responses.
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*** Can inhibit some [[T cells|T cell]] responses.
 
** '''IL-5'''
 
** '''IL-5'''
*** Activates [[Lymphocytes#B cells|B cells]].  
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*** Activates [[B cells|B cells]].  
*** Stimulates high rate [[Lymphocytes#B cells|B cells]] proliferation.  
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*** Stimulates high rate [[B cells|B cells]] proliferation.  
 
*** Promotes immunoglobulin synthesis.
 
*** Promotes immunoglobulin synthesis.
 
*** Proliferation and differentiation of eosinophils.
 
*** Proliferation and differentiation of eosinophils.
 
** '''IL-6'''  
 
** '''IL-6'''  
*** Activates [[Lymphocytes#B cells|B cells]].  
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*** Activates [[B cells|B cells]].  
*** Stimulates high rate [[Lymphocytes#B cells|B cell]] proliferation.
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*** Stimulates high rate [[B cells|B cell]] proliferation.
 
*** Promotes immunoglobulin synthesis.
 
*** Promotes immunoglobulin synthesis.
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** I.e. IFN&gamma; but not IL-2.
 
** I.e. IFN&gamma; but not IL-2.
 
*** The IFN&gamma; shifts the balance of the immune response in favour of TH<sub>1</sub> cells.
 
*** The IFN&gamma; shifts the balance of the immune response in favour of TH<sub>1</sub> cells.
**** There is therefore an increased level of [[Lymphocytes#T cells|T-cell]] proliferation.  
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**** There is therefore an increased level of [[T cells|T-cell]] proliferation.  
 
***** The initiation of the immune response via CTL leads to the selective proliferation of CTL - enhances the main mechanism of killing of virally-infected cells.  
 
***** The initiation of the immune response via CTL leads to the selective proliferation of CTL - enhances the main mechanism of killing of virally-infected cells.  
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* '''No signal 1'''
 
* '''No signal 1'''
** [[Lymphocytes#T cells|T cells]] is not activated as there is no antigen.
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** [[T cells|T cells]] is not activated as there is no antigen.
 
* '''Both signal 1 and signal 2'''
 
* '''Both signal 1 and signal 2'''
** [[Lymphocytes#T cells|T cells]] is activated into clonal expansion.
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** [[T cells|T cells]] is activated into clonal expansion.
 
*** Produces cytokines or becomes cytotoxic.  
 
*** Produces cytokines or becomes cytotoxic.  
 
** This is the response to a dangerous antigen.
 
** This is the response to a dangerous antigen.
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