The most common presenting sign in dogs is a lymphadenopathy, with only 10-20% of dogs presenting clinically unwell. Dogs that do present with clinical signs may be anorexic, lethargic and have lost weight.
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For other types of lymphoma affecting dogs the clinical signs will demonstrate the anatomical site affected.
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''Mediastinal'' forms will present with decreased heart sounds, dyspnoea and polyuria and polydypsia due to paraneoplastic hypercalcaemia.
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Dogs with mediastinal lymphoma can also have pitting oedema of the head and neck due to compression of the cranial vena cava.
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''Alimentary'' forms will present with vomiting, diarrhoea, anorexia and thickened loops on intestine on abdominal palpation.
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''Cutaneous'' lymphoma can also occur with a varied presentation but often present as cutaneous nodules.