Changes

==Pathogenesis==

==Pathogenesis==

In dogs, spores are inhaled from the environment leading to fungal colonisation of the nasal cavities. Following their deposition in tissue and recognition by phagocytes an inflammatory response is triggered. Haemolytic and dermonecrotic toxins as well as fungal protease and elastase are released leading to tissue damage.

In dogs, spores are inhaled from the environment leading to fungal colonisation of the nasal cavities. Following their deposition in tissue and recognition by phagocytes an inflammatory response is triggered. Haemolytic and dermonecrotic toxins as well as fungal protease and elastase are released leading to tissue damage.

In horses, the pathogenesis of guttural pouch mycosis is largely unknown but is thought to relate to damage to the mucosal layer of the pouches by by trauma or infection. This enables opportunistic Aspergillus fungi to invade into the damaged tissue.  

In horses, the pathogenesis of guttural pouch mycosis is largely unknown but is thought to relate to damage to the mucosal layer of the pouches by trauma or infection. This enables opportunistic Aspergillus fungi to invade into the damaged tissue.  

==Clinical signs and features==

==Clinical signs and features==