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Anticoagulant Rodenticide Toxicity (view source)
Revision as of 12:36, 23 August 2010
, 12:36, 23 August 2010→Treatment
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contraindicated, as is the administration of agents by
contraindicated, as is the administration of agents by
intramuscular injection.
intramuscular injection.
+
+If ingestion was recent (in past three hours) induce vomiting. Stomach lavage may also be indicated if dogs fail
+to vomit. Coumarin rodenticide preparations are often in the form of blue or green granules.
+*Give the specific antidote - vitamin K. Phytomenadione, a vitamin K1 analogue available as tablets or injection
+(Konakion; Roche), is the drug of choice and reverses low prothrombin levels in 30 minutes. Menadiol (Synkavit; Roche)
+is a synthetic K3 and is not as effective.
+Dose. 2 - 5 to 10 mg three times daily orally for five days because most coumarins are metabolised and excreted slowly
+over two to four days, and longer in some instances.
+If clinical signs are severe can give 5 mg intravenously over six to eight hours. However, as anaphalactic reactions
+to intravenous administration have been reported in the dog intramuscular route is preferable.
+*Give a whole blood transfusion - this replaces the clotting factors as well as replacing blood loss through haemorrhage.
==Prognosis==
==Prognosis==