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T cell differentiation (view source)
Revision as of 19:19, 25 September 2010
, 19:19, 25 September 2010→Introduction
Within the blood and lymphoid organs the majority of [[T_cells#Helper_CD4.2B|CD4+ T cells]] are antigen-naive T cells. Only a small proportion are memory T cells.
Within the blood and lymphoid organs the majority of [[T_cells#Helper_CD4.2B|CD4+ T cells]] are antigen-naive T cells. Only a small proportion are memory T cells.
Naive T cells have yet to encounter antigen and can only be activated by antigen that is presented by dendritic cells. After initial antigenic activation, naïve T-cells develop into an intermediate stage cell called the TH<sub>0</sub> cell which can then be activated by any antigen-presenting cell, e.g. Dendritic cells, [[Macrophages|macrophages]] or [[B cells|B-cells]].
Naive T cells have yet to encounter antigen and can only be activated by antigen that is presented by dendritic cells. After initial antigenic activation, naïve T-cells develop into an intermediate stage cell called the TH<sub>0</sub> cell which can then be activated by any antigen-presenting cell, e.g. Dendritic cells, [[Macrophages|macrophages]] or [[B cells]].
The TH<sub>0</sub> cells have the capacity to differentiate into TH<sub>1</sub> and TH<sub>2</sub> cells. The type of cell that develops depends on the antigen presenting cell type. [[Macrophages|Macrophages]] cause the TH<sub>0</sub> cell to develop into a TH<sub>1</sub> cell induced by IL-12 production following [[Macrophages|macrophage]]-antigen interaction. [[B cells|B cells]] cause the TH<sub>0</sub> cell to develop into a TH<sub>2</sub> cell induced by IL-10 production following B cell-antigen interaction. On antigenic stimulation the TH<sub>1</sub> or TH<sub>2</sub> cells become activated, undergo clonal expansion and secrete a range of different cytokines.
The TH<sub>0</sub> cells have the capacity to differentiate into TH<sub>1</sub> and TH<sub>2</sub> cells. The type of cell that develops depends on the antigen presenting cell type. [[Macrophages|Macrophages]] cause the TH<sub>0</sub> cell to develop into a TH<sub>1</sub> cell induced by IL-12 production following macrophage-antigen interaction. B cells cause the TH<sub>0</sub> cell to develop into a TH<sub>2</sub> cell induced by IL-10 production following B cell-antigen interaction. On antigenic stimulation the TH<sub>1</sub> or TH<sub>2</sub> cells become activated, undergo clonal expansion and secrete a range of different cytokines.
For any one cell the cytokine-secreting activation state is short-lived, lasting between 4 - 40 hours. After this time these cells either die or mature into the long-lived memory cells. The proliferation of [[T cells]] continues until the presentation of antigen ceases.
For any one cell the cytokine-secreting activation state is short-lived, lasting between 4 - 40 hours. After this time these cells either die or mature into the long-lived memory cells. The proliferation of [[T cells]] continues until the presentation of antigen ceases.