Changes

<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes.

<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with humoral immunity. They represent 20-30% of circulating lymphocytes.

B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody  [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>

B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody  [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>

<p>Under antigenic stimulation B cells differentiate into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>

<p>Under antigenic stimulation |[[B cell differentiationB cells differentiate]] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>

B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to [[T cells]] on [[Major Histocompatability Complexes#MHC II|MHC II]].

B-cells also act as Antigen-Presenting Cells (APCs) by presenting digested fragments to [[T cells]] on [[Major Histocompatability Complexes#MHC II|MHC II]].