Changes

[[Image:B-cell immunity.jpg|thumb|right|250pxl|B-cell differentiation - B. Catchpole, RVC 2008]]

[[Image:B-cell immunity.jpg|thumb|right|250pxl|B-cell differentiation - B. Catchpole, RVC 2008]]

==Introduction==

==Introduction==

<p>Mature [[Lymphocytes#B cells|B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either [[#Plasma cells|plasma]] or [[#Memory cells|memory]] cells. </p>

<p>Mature [[B cells]] that undergo stimulation by an antigen undergo class switching, and differentiate into either [[#Plasma cells|plasma]] or [[#Memory cells|memory]] cells. </p>

<p>In the paracortex region of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] binding to MHC II and the presence of Il-4 produced by [[Lymphocytes#Helper CD4+|CD4⁺ T cells]] (Th2 type) causes [[Lymphocytes#B cells|B cells]] to differentiate. Most [[Lymphocytes#B cells|B cells]] become [[#Plasma cells|plasma cells]], however small number become [[#Memory cells|memory cells]] .</p>

<p>In the paracortex region of [[Lymph Nodes - Anatomy & Physiology|lymph nodes]] binding to MHC II and the presence of Il-4 produced by [[Lymphocytes#Helper CD4+|CD4⁺ T cells]] (Th2 type) causes [[Lymphocytes#B cells|B cells]] to differentiate. Most [[Lymphocytes#B cells|B cells]] become [[#Plasma cells|plasma cells]], however small number become [[#Memory cells|memory cells]] .</p>