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B cell differentiation (view source)
Revision as of 09:53, 27 September 2010
, 09:53, 27 September 2010→Introduction
<p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of Il-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however small number become memory cells.</p>
<p>In the paracortex region of the [[Lymph Nodes - Anatomy & Physiology|lymph node]] binding to [[Major_Histocompatability_Complexes#MHC_II|MHC II]] in the presence of Il-4 produced by the [[Lymphocytes#Helper CD4+|CD4<sup>+</sup> T cells]] (Th2 type) causes the B cells to differentiate; most will become plasma cells, however small number become memory cells.</p>
Follicular dendritic cells absorb antigen onto their surface to present to B cells to stimulate differentiation.
Follicular dendritic cells present in the germinal centers of peripheral lymphoid organs can absorb intact antigen onto their surface to present to B cells to stimulate differentiation.
==Plasma cells==
==Plasma cells==