Changes

Also known as '''''B lymphocytes

Also known as '''''B lymphocytes

<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the [[:Category:Adaptive Immune System|'''adaptive immune system''']]. They represent 20-30% of circulating lymphocytes.

<p>So named as they were initially found in the [[Bursa of Fabricius - Anatomy & Physiology|Bursa of Fabricius]], B cells produce antibodies (Ig’s) and are associated with '''humoral immunity''' (T cells are part of the cell-mediated immune response), and are an integral part of the [[:Category:Adaptive Immune System|'''adaptive immune system''']]. They represent 20-30% of circulating lymphocytes.

B cells have B cell receptors (BCRs), or antigen binding sites which combine as the antibody  [[IgM]] when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>

 

B cells have cell surface proteins known as B cell receptors (BCRs) that are known as immunoglobulins; [[IgM]] is the membrane bound BCR that is expressed when the B cell is immature, changing to [[IgD]] when the cell is mature. IgM has a large molecular mass and can bind up to 10 antigens simultaneously. B cells also express MHC II, CD9, CD,19, CD20 and CD24.</p>

<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>

<p>Under antigenic stimulation B cells [[B cell differentiation|'''differentiate''']] into [[B cell differentiation#Plasma cells|plasma cells]] and [[B cell differentiation#Memory cells|memory cells]].</p>