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T cell differentiation (view source)
Revision as of 16:54, 27 September 2010
, 16:54, 27 September 2010→TH1 Cells
TH<sub>1</sub> cells secrete a range of cytokines, including:
TH<sub>1</sub> cells secrete a range of cytokines, including:
* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4+]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8+ T-cells]]. This stimulation of T cell proliferation is the main function of the TH<sub>1</sub> cell.
* '''IL-2''', which induces proliferation of both [[Helper_CD4%2B#Helper_CD4.2B|CD4+]] and [[Cytotoxic_CD8%2B#Cytotoxic_CD8.2B|CD8+ T-cells]]. This stimulation of T cell proliferation is the main function of the TH<sub>1</sub> cell.
* '''Interferon gamma''' ('''IFNγ''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. Interferon gamma activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically:
* '''Interferon gamma''' ('''IFNγ''') which activates tissue macrophages and is the principal effector mechanism in the defence against intracellular bacteria and parasites such as Mycobacteria, Brucella, Rickettsia Leishmania, Coccidia, and Babesia. IFNγ activates macrophages and stimulates them to produce enzymes triggering intracellular killing mechanisms - specifically:
#Superoxide dismutase and myeloperoxidase that produce H<sub>2</sub>O<sub>2</sub> and trigger the "superoxide burst".
#Superoxide dismutase and myeloperoxidase that produce H<sub>2</sub>O<sub>2</sub> and trigger the "superoxide burst".
#Nitric oxide synthase which produces nitric oxide.
#Nitric oxide synthase which produces nitric oxide.