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→Monocyte development
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==Monocyte development==
==Monocytes==
[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
[[Monocytes|Monocytes]] develop from the same precursor as [[Neutrophils|neutrophils]] the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]]. This then differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]] under the influence of GM-CSF, IL-3 and M-CSF.
===Stages===
===Stages:===
====Monoblast====
====Monoblast====
First stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].
First stage after cell has differentiated into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-M]].
====Promonocyte====
====Promonocyte====
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
Cell has a large nucleus and basophilic cytoplasm and consists of two populations:- One rapidly dividing and the other slowly dividing (acting as a reservoir).
====Monocyte====
====[[Monocytes|Monocyte]]====
Monocytes are incapable of mitosis and enter circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm.
Monocytes are incapable of mitosis and enter circulation. They have a large kidney shaped nucleus with a slightly basophilic cytoplasm.
====[[Macrophages|Macrophage]]====
====Macrophage====
Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].
Once the monocyte has entered tissue it differentiates into a [[Macrophages|macrophage]].
===Dendritic cells===
===Dendritic cells===
Develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.
Develop from the monoblast under the stimualtion of GM-CSF and IL-4 into an immature dendritic cell. This then develops into the mature dendritic cell under stimulation of TNF-α.