Changes

This condition is seen in the dog, most frequently in Scottish Terriers and Chesapeake Bay Retrievers. It has become more prevalent recently in Dobermanns, Setters and German Shepherd dogs. A similar disease has been recorded in the pig.  

This condition is seen in the dog, most frequently in Scottish Terriers and Chesapeake Bay Retrievers. It has become more prevalent recently in Dobermanns, Setters and German Shepherd dogs. A similar disease has been recorded in the pig.  

   

   

Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression.

Von Willebrand's Disease is an inherited autosomal recessive trait. It is incompletely dominant, so there is variable expression. It can present as purpura and/or prolonged bleeding times. Pathologically, there is reduced platelet adhesiveness and low Factor XIII levels.

 

The disease can be assessed by the measurement of Von Willebrand Factor protein levels.

* Prolonged bleeding time.

* Reduced platelet adhesiveness.

* Low Factor XIII levels.

* The disease can be assessed by the measurement of Von Willebrand Factor protein levels.

** A Factor VIII-related protein.

** A Factor VIII-related protein.

** Synthesised in endothelial cells and megakaryocytes.

** Synthesised in endothelial cells and megakaryocytes.