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Also known as '''''Idiopathic Thrombocytopaenic Purpura, Evan’s Syndrome

| Also known as:

| '''Idiopathic Thrombocytopaenic Purpura'''<br>

'''Evan’s Syndrome'''

==Description==

==Introduction==

Immune-mediated thrombocytopaenia (ITP) occurs due to an autoimmune response directed against circulating platelets or megakaryocytes in the bone marrow.  The destruction of cells is mediated by antibodies, making ITP a form of '''[[Type II Hypersensitivity|type II hypersensitivity]]'''.  The antibodies bind to cells and act as a foundation for the assembly of serum complement components or as opsonins, promoting the uptake and destruction of platelets by cells of the monocyte-phagocyte system (MPS).  The destruction of platelets usually results in severe [[Platelet Abnormalities|thrombocytopaenia]] and, if the blood level of platelets fall below approximately 50x10^9/l, the affected animal is at risk of mucosal haemorrhages.   

Immune-mediated thrombocytopaenia (ITP) occurs due to an autoimmune response directed against circulating platelets or megakaryocytes in the bone marrow.  The destruction of cells is mediated by antibodies, making ITP a form of '''[[Type II Hypersensitivity|type II hypersensitivity]]'''.  The antibodies bind to cells and act as a foundation for the assembly of serum complement components or as opsonins, promoting the uptake and destruction of platelets by cells of the monocyte-phagocyte system (MPS).  The destruction of platelets usually results in severe [[Platelet Abnormalities|thrombocytopaenia]] and, if the blood level of platelets fall below approximately 50x10^9/l, the affected animal is at risk of mucosal haemorrhages.