Changes

In the event of blood pressure dropping [[Kidney Endocrine Function - Anatomy & Physiology#Renin|Renin]] is secreted due to the decreased stretch of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Juxtaglomerular Cells|'''juxtaglomerular cells''']] and an increased sympathetic stimulation triggered by the decreased activation of arterial baroreceptors.  This enzyme cleaves the alpha glycoprotein '''Angiotensinogen''' which is released from the [[Liver - Anatomy & Physiology|liver]].  This produces '''Angiotensin 1''' which is further converted by [[Angiotensin Converting Enzyme(ACE) - Renal Anatomy & Physiology|'''Angiotensin Converting Enzyme''' (ACE)]] to '''Angiotensin II''' mainly in the lungs but to a much lesser extent locally in the kidneys.  Angiotensin 2 then works to restore blood pressure by inducing constriction of arterioles, which increases vascular resistance, and constricting veins which reduces vascular volume. In this section we cover its effects on and through the kidneys.

In the event of blood pressure dropping [[Kidney Endocrine Function - Anatomy & Physiology#Renin|Renin]] is secreted due to the decreased stretch of the [[Reabsorption and Secretion Along the Distal Tubule and Collecting Duct - Anatomy & Physiology#Juxtaglomerular Cells|'''juxtaglomerular cells''']] and an increased sympathetic stimulation triggered by the decreased activation of arterial baroreceptors.  This enzyme cleaves the alpha glycoprotein '''Angiotensinogen''' which is released from the [[Liver - Anatomy & Physiology|liver]].  This produces '''Angiotensin 1''' which is further converted by [[Angiotensin Converting Enzyme(ACE) - Renal Anatomy & Physiology|'''Angiotensin Converting Enzyme''' (ACE)]] to '''Angiotensin II''' mainly in the lungs but to a much lesser extent locally in the kidneys.  Angiotensin 2 then works to restore blood pressure by inducing constriction of arterioles, which increases vascular resistance, and constricting veins which reduces vascular volume. In this section we cover its effects on and through the kidneys.

==Effects of Angiotensin 2 on Blood Pressure==

==Effects of Angiotensin II on Blood Pressure==

'''Angiotensin II''' acts on '''AT1 receptors''' to stimulate the release of '''[[Aldosterone|aldosterone]]''' from the [[Adrenal Glands - Anatomy & Physiology#Adrenal Glands|zona glomerulosa]] of the adrenal glands.  This mineralocorticoid increases the reabsorption of sodium and therefore water and chloride from the distal tubule of the kidney, thus helping to increase blood pressure and volume. It also stimulates the thirst center and increases the secretion of [[Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland |anti-diuretic hormone (ADH)]] to help increase blood volume. The RAAS allows pressure to return to 50% of baseline within 15 minutes of a significant haemorrhage occuring.

'''Angiotensin II''' acts on '''AT1 receptors''' to stimulate the release of '''[[Aldosterone|aldosterone]]''' from the [[Adrenal Glands - Anatomy & Physiology#Adrenal Glands|zona glomerulosa]] of the adrenal glands.  This mineralocorticoid increases the reabsorption of sodium and therefore water and chloride from the distal tubule of the kidney, thus helping to increase blood pressure and volume. It also stimulates the thirst center and increases the secretion of [[Pituitary Gland - Anatomy & Physiology #Posterior Pituitary Gland |anti-diuretic hormone (ADH)]] to help increase blood volume. The RAAS allows pressure to return to 50% of baseline within 15 minutes of a significant haemorrhage occuring.