Changes

==Diagnosis==

==Diagnosis==

===Clinical Signs===

===Clinical Signs===

Includes: twitching, convulsions, ataxia, hypersalivation, emesis, diarrhoea, hyperaesthesia, muscle fasciculations, lethargy, tachycardia, anxiety, temporary blindness,death <ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>, <ref name="multiples"> '''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>.   

Includes: twitching, convulsions, ataxia, hypersalivation, respiratory distress, emesis, diarrhoea, hyperaesthesia, muscle fasciculations, lethargy, tachycardia, anxiety, temporary blindness,death <ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>, <ref name="multiples"> '''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>.   

===Laboratory Tests===

===Laboratory Tests===

===Pathology===

===Pathology===

The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>.  Cats lack the enzyme glucuronidase transferase <ref> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>

The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>.  Cats lack the enzyme glucuronidase transferase <ref name="multiples"> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>

==Treatment==

==Treatment==

==Prognosis==

==Prognosis==

==References==

==References==

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