Paraquat Poisoning

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  • In dogs and cats
  • Free radical release causes damage to air-blood barrier
  • Depending on the dose, the lesions range from acute lesions (oedema, haemorrhage, hyaline membranes) -> chronic (fibroplasia of alveolar septae, replacement of alveolar cells with type II cells)
  • Additional extrapulmonary lesions to note following paraquat intoxication are necrosis of the adrenal zona glomerulosa and renal tubular epithelium