Drugs Acting on the Intestines

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GASTROINTESTINAL DRUGS


Drugs Increasing Smooth Muscle Contractility

These drugs are used for conditions that are associated with hypomotility, such as megacolon, oesophageal reflux, atony and ileus.

Drugs Acting on 5-HT4 Receptors

  • An examples is metoclopramide that is an agonist at serotonin and dopamine receptors, this results in an increased release of acetylcholine and so increases gut motility.

Muscarinic Receptor Agonists

  • Examples are carbachol and bethanecol. They should be used with slight caution as their resultant contractions can be painful.

Laxatives and Purgatives

Drugs Decreasing Smooth Muscle Contractility

Other Drugs