Alpha-2 Agonists

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Alpha-2 agonists have sedative, anxiolytic and analgesic effects.

Mechanism of Action

Alpha-2 agonists act on alpha-2 adrenoreceptors, and mimic the effects of the actual ligand binding. The sedative and anxiolytic effects arise from this process leading to pre-synaptic inhibition of noradrenaline release.

Actions

Side Effects and Contraindications

Drugs in this Group

Xylazine

Detomidine

Medetomidine

Romifidine