Levamisole
Revision as of 21:28, 29 September 2009 by Amazonian (talk | contribs) (New page: ==Levamisole== * This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on. * It is active against adult '''Nematodes''', but has limited ...)
Levamisole
- This is one of the most widely used anthelmintics and can be given orally, by injection or as a pour on.
- It is active against adult Nematodes, but has limited action against the larval stages, especially the hypobiotic phase.
- It is a cholinergic agonist at neural and neuromuscular junctions causing a spastic paralysis of the nematode. The nematodes succumb rapidly to it.
- It is rapidly absorbed and excreted and its potency is related to its peak plasma concentrations. Therefore pour-on products need a higher dose, as they are absorbed more slowly, to reach the same plasma concentrations.